[HTML][HTML] A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models

A Cheng, W Jia, I Kawahata, K Fukunaga - EBioMedicine, 2021 - thelancet.com
… ; targeted inhibition of the two proteins may confer potential therapeutic effects in MS … mouse
model (experimental autoimmune encephalomyelitis [EAE] mice), suggesting novel protein

[HTML][HTML] Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages

Y Xiao, L Shu, X Wu, Y Liu, LY Cheong, B Liao, X Xiao… - JCI insight, 2021 - ncbi.nlm.nih.gov
… Here we show that circulating fatty acid binding protein 4 (… autoimmune
encephalomyelitis/multiple sclerosis (19–21). FABP4-deficient mice exhibit a lower incidence of …

The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis

T Paskevicius, J Jung, M Pujol, P Eggleton… - The FASEB …, 2020 - Wiley Online Library
… -tail domain of Canx in conferring sensitivity to EAE induction, … protein (psoriasis-associated
fatty acid-binding protein [PA-… in epidermal-type fatty acid binding protein-deficient mice. J …

Fatty acid binding protein (Fabp) 5 interacts with the calnexin cytoplasmic domain at the endoplasmic reticulum

J Jung, J Wang, J Groenendyk, D Lee… - Biochemical and …, 2017 - Elsevier
… of experimental autoimmune encephalomyelitis (EAE) … As Fabp5-deficient mice show protection
from the clinical … -tail domain may have an important role in conferring resistance to EAE. …

[HTML][HTML] Fatty acid-binding proteins: their roles in ischemic stroke and potential as drug targets

Q Guo, I Kawahata, A Cheng, W Jia, H Wang… - International journal of …, 2022 - mdpi.com
… response in an experimental autoimmune encephalomyelitis (EAE) mouse model of … death
in a myocardial infarction mouse model, whereas deficiency in FABP3 can effectively prevent …

[HTML][HTML] Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling

AV Hertzel, H Xu, M Downey, N Kvalheim… - Journal of lipid …, 2017 - ASBMB
… Previous studies have shown that reduced levels of the adipocyte fatty acid binding
protein (FABP)4 (AFABP/aP2), result in metabolic improvement including potentiated insulin …

[HTML][HTML] Mice lacking fatty acid-binding protein 5 are resistant to listeria monocytogenes

DM Rao, DT Phan, MJ Choo, AL Owen… - Journal of Innate …, 2019 - karger.com
… These data suggest that FABP5 deficiency in immune cells confers heightened protection
from L. monocytogenes infection. In addition, because tissue-resident macrophages are radio-…

[HTML][HTML] Fatty acidbinding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation

D Bogdan, J Falcone, MP Kanjiya, SH Park… - Journal of Biological …, 2018 - ASBMB
Fatty acidbinding proteins (FABPs) are intracellular lipid carriers that regulate inflammation,
and … In mice, intraplantar injection of carrageenan induces acute inflammation that is …

[HTML][HTML] Impact of fatty acid-binding proteins in α-synuclein-induced mitochondrial injury in synucleinopathy

A Cheng, W Jia, I Kawahata, K Fukunaga - Biomedicines, 2021 - mdpi.com
… , in experimental autoimmune encephalomyelitis (EAE) in a mouse model of MS, the deficiency
of FABP5 indicated a protective effect from the development of EAE [129,130]. Dendritic …

Stearic acid induces CD11c expression in proinflammatory macrophages via epidermal fatty acid binding protein

J Zeng, Y Zhang, J Hao, Y Sun, S Liu… - The Journal of …, 2018 - journals.aai.org
… the unsaturated FA diet, developed a skin lesion. Interestingly, A-FABP deficiency failed to
protect mice against cocoa butter–induced skin lesions (7 of 14 mice exhibiting skin lesions in …